A meteorite crashes into Colepepper Zoo, releasing a virus that turns the animals into mutant zombies. Gracie, a young wolf, teams up with a gruff mountain lion named Dan to find a way back to her pack.

As the zoo becomes overrun, they try to devise a plan to restore the animals to normal. With the help of a group of survivors—Xavier, the film-obsessed lemur; Frida, the impulsive capybara; Ash, the comical ostrich; and Félix, the treacherous monkey—they embark on a dangerous mission to save the zoo and defeat Bunny Zero, the mutant king determined to spread the virus beyond the zoo walls.